WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=14; E=3.00; R=4.67; rawP=2.48e-06; adjP=7.19e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
2  ENSG00000139687 NA RB1 retinoblastoma 1 5925 ENSG00000139687
3  ENSG00000152284 NA TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 83439 ENSG00000152284
4  ENSG00000175387 NA SMAD2 SMAD family member 2 4087 ENSG00000175387
5  ENSG00000056558 NA TRAF1 TNF receptor-associated factor 1 7185 ENSG00000056558
6  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
7  ENSG00000070388 NA FGF22 fibroblast growth factor 22 27006 ENSG00000070388
8  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966
9  ENSG00000160271 NA RALGDS ral guanine nucleotide dissociation stimulator 5900 ENSG00000160271
10  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
11  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
12  ENSG00000105976 NA MET met proto-oncogene (hepatocyte growth factor receptor) 4233 ENSG00000105976
13  ENSG00000004975 NA DVL2 dishevelled, dsh homolog 2 (Drosophila) 1856 ENSG00000004975
14  ENSG00000196591 NA HDAC2 histone deacetylase 2 3066 ENSG00000196591


Database:KEGG pathway       Name:Lysosome       ID:04142
C=121; O=9; E=1.11; R=8.08; rawP=1.98e-06; adjP=7.19e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135677 NA GNS glucosamine (N-acetyl)-6-sulfatase 2799 ENSG00000135677
2  ENSG00000005893 NA LAMP2 lysosomal-associated membrane protein 2 3920 ENSG00000005893
3  ENSG00000197217 NA ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 9583 ENSG00000197217
4  ENSG00000141367 NA CLTC clathrin, heavy chain (Hc) 1213 ENSG00000141367
5  ENSG00000213614 NA HEXA hexosaminidase A (alpha polypeptide) 3073 ENSG00000213614
6  ENSG00000081014 NA AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 23431 ENSG00000081014
7  ENSG00000127415 NA IDUA iduronidase, alpha-L- 3425 ENSG00000127415
8  ENSG00000185009 NA AP3M1 adaptor-related protein complex 3, mu 1 subunit 26985 ENSG00000185009
9  ENSG00000003056 NA M6PR mannose-6-phosphate receptor (cation dependent) 4074 ENSG00000003056


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=29; E=10.40; R=2.79; rawP=9.01e-07; adjP=7.19e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138018 NA EPT1 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) 85465 ENSG00000138018
2  ENSG00000168002 NA POLR2G polymerase (RNA) II (DNA directed) polypeptide G 5436 ENSG00000168002
3  ENSG00000135002 NA RFK riboflavin kinase 55312 ENSG00000135002
4  ENSG00000169764 NA UGP2 UDP-glucose pyrophosphorylase 2 7360 ENSG00000169764
5  ENSG00000018510 NA AGPS alkylglycerone phosphate synthase 8540 ENSG00000018510
6  ENSG00000037757 NA MRI1 methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) 84245 ENSG00000037757
7  ENSG00000144231 NA POLR2D polymerase (RNA) II (DNA directed) polypeptide D 5433 ENSG00000144231
8  ENSG00000171155 NA C1GALT1C1 C1GALT1-specific chaperone 1 29071 ENSG00000171155
9  ENSG00000147416 NA ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 526 ENSG00000147416
10  ENSG00000148606 NA POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 11128 ENSG00000148606
11  ENSG00000151665 NA PIGF phosphatidylinositol glycan anchor biosynthesis, class F 5281 ENSG00000151665
12  ENSG00000130649 NA CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1571 ENSG00000130649
13  ENSG00000139133 NA ALG10 asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe) 84920 ENSG00000139133
14  ENSG00000135677 NA GNS glucosamine (N-acetyl)-6-sulfatase 2799 ENSG00000135677
15  ENSG00000136628 NA EPRS glutamyl-prolyl-tRNA synthetase 2058 ENSG00000136628
16  ENSG00000127080 NA IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 64768 ENSG00000127080
17  ENSG00000159131 NA GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 2618 ENSG00000159131
18  ENSG00000100479 NA POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5427 ENSG00000100479
19  ENSG00000140459 NA CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1583 ENSG00000140459
20  ENSG00000048392 NA RRM2B ribonucleotide reductase M2 B (TP53 inducible) 50484 ENSG00000048392
21  ENSG00000015532 NA XYLT2 xylosyltransferase II 64132 ENSG00000015532
22  ENSG00000122884 NA P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 5033 ENSG00000122884
23  ENSG00000163527 NA STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) 201595 ENSG00000163527
24  ENSG00000168710 NA AHCYL1 adenosylhomocysteinase-like 1 10768 ENSG00000168710
25  ENSG00000109929 NA SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 6309 ENSG00000109929
26  ENSG00000213614 NA HEXA hexosaminidase A (alpha polypeptide) 3073 ENSG00000213614
27  ENSG00000127415 NA IDUA iduronidase, alpha-L- 3425 ENSG00000127415
28  ENSG00000087111 NA PIGS phosphatidylinositol glycan anchor biosynthesis, class S 94005 ENSG00000087111
29  ENSG00000120137 NA PANK3 pantothenate kinase 3 79646 ENSG00000120137


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=9; E=1.24; R=7.24; rawP=4.88e-06; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000198642 NA KLHL9 kelch-like 9 (Drosophila) 55958 ENSG00000198642
2  ENSG00000153827 NA TRIP12 thyroid hormone receptor interactor 12 9320 ENSG00000153827
3  ENSG00000078747 NA ITCH itchy E3 ubiquitin protein ligase 83737 ENSG00000078747
4  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966
5  ENSG00000142230 NA SAE1 SUMO1 activating enzyme subunit 1 10055 ENSG00000142230
6  ENSG00000148634 NA HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 26091 ENSG00000148634
7  ENSG00000185019 NA UBOX5 U-box domain containing 5 22888 ENSG00000185019
8  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
9  ENSG00000033178 NA UBA6 ubiquitin-like modifier activating enzyme 6 55236 ENSG00000033178


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=9; E=1.52; R=5.93; rawP=2.46e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119318 NA RAD23B RAD23 homolog B (S. cerevisiae) 5887 ENSG00000119318
2  ENSG00000071537 NA SEL1L sel-1 suppressor of lin-12-like (C. elegans) 6400 ENSG00000071537
3  ENSG00000116406 NA EDEM3 ER degradation enhancer, mannosidase alpha-like 3 80267 ENSG00000116406
4  ENSG00000102595 NA UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 55757 ENSG00000102595
5  ENSG00000118217 NA ATF6 activating transcription factor 6 22926 ENSG00000118217
6  ENSG00000163527 NA STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) 201595 ENSG00000163527
7  ENSG00000136731 NA UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 56886 ENSG00000136731
8  ENSG00000127022 NA CANX calnexin 821 ENSG00000127022
9  ENSG00000067167 NA TRAM1 translocation associated membrane protein 1 23471 ENSG00000067167


Database:KEGG pathway       Name:Chronic myeloid leukemia       ID:05220
C=73; O=6; E=0.67; R=8.93; rawP=5.93e-05; adjP=0.0009
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
2  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
3  ENSG00000139687 NA RB1 retinoblastoma 1 5925 ENSG00000139687
4  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
5  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
6  ENSG00000196591 NA HDAC2 histone deacetylase 2 3066 ENSG00000196591


Database:KEGG pathway       Name:Purine metabolism       ID:00230
C=162; O=8; E=1.49; R=5.36; rawP=0.0001; adjP=0.0011
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000159131 NA GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 2618 ENSG00000159131
2  ENSG00000197217 NA ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 9583 ENSG00000197217
3  ENSG00000100479 NA POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5427 ENSG00000100479
4  ENSG00000168002 NA POLR2G polymerase (RNA) II (DNA directed) polypeptide G 5436 ENSG00000168002
5  ENSG00000048392 NA RRM2B ribonucleotide reductase M2 B (TP53 inducible) 50484 ENSG00000048392
6  ENSG00000112541 NA PDE10A phosphodiesterase 10A 10846 ENSG00000112541
7  ENSG00000144231 NA POLR2D polymerase (RNA) II (DNA directed) polypeptide D 5433 ENSG00000144231
8  ENSG00000148606 NA POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 11128 ENSG00000148606


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=9; E=1.85; R=4.86; rawP=0.0001; adjP=0.0011
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000175387 NA SMAD2 SMAD family member 2 4087 ENSG00000175387
2  ENSG00000170248 NA PDCD6IP programmed cell death 6 interacting protein 10015 ENSG00000170248
3  ENSG00000115145 NA STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 10254 ENSG00000115145
4  ENSG00000078747 NA ITCH itchy E3 ubiquitin protein ligase 83737 ENSG00000078747
5  ENSG00000141367 NA CLTC clathrin, heavy chain (Hc) 1213 ENSG00000141367
6  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
7  ENSG00000124313 NA IQSEC2 IQ motif and Sec7 domain 2 23096 ENSG00000124313
8  ENSG00000105976 NA MET met proto-oncogene (hepatocyte growth factor receptor) 4233 ENSG00000105976
9  ENSG00000124209 NA RAB22A RAB22A, member RAS oncogene family 57403 ENSG00000124209


Database:KEGG pathway       Name:Acute myeloid leukemia       ID:05221
C=57; O=5; E=0.52; R=9.53; rawP=0.0002; adjP=0.0017
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
2  ENSG00000108443 NA RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 6198 ENSG00000108443
3  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
4  ENSG00000152284 NA TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 83439 ENSG00000152284
5  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904


Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=6; E=0.80; R=7.49; rawP=0.0002; adjP=0.0017
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
2  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
3  ENSG00000169598 NA DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 1677 ENSG00000169598
4  ENSG00000114302 NA PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 5576 ENSG00000114302
5  ENSG00000187446 NA CHP1 calcineurin-like EF hand protein 1 11261 ENSG00000187446
6  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).